Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute renal failure.

Sharon Phillips Andreoli1

  • 1Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University Medical Center, Indianapolis, Indiana 46202, USA. sandreol@uipui.edu

Current Opinion in Pediatrics
|May 1, 2002
PubMed
Summary

Hypoxic/ischemic acute renal failure is common in hospitalized children. New insights into its causes and treatments, like hemofiltration, are improving care for pediatric acute kidney injury.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors affecting dialysis duration in children with Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome.

Pediatric nephrology (Berlin, Germany)·2023
Same author

The importance of extra-renal involvement in the hemolytic uremic syndrome.

Pediatric nephrology (Berlin, Germany)·2022
Same author

Acute kidney injury in children.

Pediatric nephrology (Berlin, Germany)·2008
Same author

Acute renal failure in the newborn.

Seminars in perinatology·2004

Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine

Background:

  • Acute renal failure (ARF) in children presents with elevated creatinine and nitrogenous waste, impairing fluid and electrolyte balance.
  • Causes include prerenal disease, intrinsic renal failure (e.g., hypoxic/ischemic insults), and obstructive uropathy.

Purpose of the Study:

  • Focus on hypoxic/ischemic ARF, a frequent cause of hospital-acquired ARF in children.
  • Review pediatric ARF epidemiology, incidence, and novel pathogenetic insights.
  • Discuss evolving therapeutic strategies for pediatric ARF.

Main Methods:

  • Literature review focusing on hypoxic/ischemic acute renal failure in pediatric populations.
  • Analysis of recent findings on ARF pathogenesis, including nitric oxide/endothelin metabolism, inflammation, and polarity.
  • Evaluation of current and emerging treatment modalities.

Main Results:

  • Hypoxic/ischemic insults are a primary driver of hospital-acquired ARF in children.
  • Pathogenesis involves complex hemodynamic, inflammatory, and cellular polarity changes.
  • "Renal dose" dopamine has proven ineffective in adults; hemofiltration is gaining traction.

Conclusions:

  • Understanding the pathophysiology of pediatric ARF is crucial for effective management.
  • Therapeutic approaches are shifting, with hemofiltration emerging as a key treatment option.
  • Continued research is needed to optimize the care of children with acute kidney injury.

Related Experiment Videos