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Related Experiment Videos

Nighttime versus daytime hypnotic self-administration.

Timothy Roehrs1, Alicia Bonahoom, Bonita Pedrosi

  • 1Henry Ford Hospital, Sleep Disorders and Research Center, 2799 West Grand Boulevard, CFP-3, Detroit, MI 48202, USA. taroehrs@aol.com

Psychopharmacology
|May 1, 2002
PubMed
Summary
This summary is machine-generated.

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Insomniacs who self-administer hypnotics during the day show physiological arousal, and the medication reduces it. This suggests therapy-seeking behavior rather than drug-seeking behavior for daytime hypnotic use.

Area of Science:

  • Sleep Medicine
  • Psychopharmacology
  • Behavioral Science

Background:

  • Insomnia is often treated with hypnotics, with previous research indicating high rates of self-administration at night.
  • The extent to which insomniacs self-administer hypnotics during daytime hours remains less understood.
  • Understanding daytime hypnotic use is crucial for assessing treatment-seeking behaviors in insomnia.

Purpose of the Study:

  • To investigate whether insomniacs' self-administration of hypnotics extends to daytime use.
  • To compare daytime and nighttime hypnotic preferences in individuals with and without insomnia.
  • To explore the physiological underpinnings of daytime hypnotic self-administration in insomniacs.

Main Methods:

  • Forty-four participants (22 with insomnia, 22 without) were randomized to triazolam doses (0.125 or 0.25 mg).

Related Experiment Videos

  • Hypnotic preference (triazolam vs. placebo) was assessed over 7 days during both nighttime and daytime phases.
  • Daytime alertness was measured using the Multiple Sleep Latency Test (MSLT), alongside mood and performance assessments.

    • Main Results:

    • Triazolam was chosen more frequently at night than during the day across all participants.
    • Insomniacs showed consistent triazolam preference between day and night, unlike normal sleepers who preferred it less during the day.
    • A significant portion of insomniacs (40%) opted for triazolam on most daytime sampling days, and it reduced their objective sleepiness (MSLT).

    Conclusions:

    • Daytime hypnotic self-administration by a subset of insomniacs is linked to physiological arousal.
    • Triazolam's ability to reduce daytime arousal suggests that this behavior is primarily therapy-seeking.
    • Findings support the notion that daytime hypnotic use in insomniacs, short-term, aligns with therapeutic goals rather than recreational drug-seeking.