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Related Experiment Videos

Reduced aggression in mice lacking the serotonin transporter.

Andrew Holmes1, Dennis L Murphy, Jacqueline N Crawley

  • 1Section on Behavioral Genomics, National Institute of Mental Health, Building 10 Room 4D11, Bethesda, MD 20892-1375, USA. aholmes@intra.nimh.nih.gov

Psychopharmacology
|May 1, 2002
PubMed
Summary

Mice lacking the serotonin transporter (5-HTT) gene showed reduced aggression and activity. This suggests that 5-HTT dysfunction may influence aggressive behaviors and receptor function.

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Area of Science:

  • Neuroscience
  • Behavioral Genetics

Background:

  • Serotonergic system dysregulation is linked to aggression.
  • The serotonin transporter (5-HTT) is crucial for central serotonergic activity.
  • 5-HTT dysfunction may mediate pathological aggression.

Purpose of the Study:

  • To evaluate aggressive behavior in 5-HTT knockout (KO) mice.
  • To investigate home cage activity in 5-HTT KO mice.
  • To examine 5-HT(1A/1B) receptor function in 5-HTT KO mice.

Main Methods:

  • Resident-intruder test to assess aggression in isolated male 5-HTT KO and control mice.
  • Home cage activity monitoring over 24 hours.
  • Pharmacological assessment of 5-HT(1A/1B) receptor function using RU24969.

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Main Results:

  • 5-HTT -/- mice exhibited delayed and less frequent attacks but normal social investigation.
  • 5-HTT +/- mice showed reduced overall attacks compared to controls.
  • Aggression increased with repeated intruder exposure in 5-HTT +/- and +/+ mice, but not in 5-HTT -/- mice.
  • 5-HTT -/- mice displayed reduced overall home cage activity.
  • RU24969 did not induce hyperlocomotion in 5-HTT -/- mice.

Conclusions:

  • Serotonin transporter gene deletion reduces aggressive behavior and home cage activity.
  • Desensitized 5-HT(1A/1B) receptor function may underlie the diminished aggression in 5-HTT KO mice.