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Updated: May 12, 2026

Heterokaryon Technique for Analysis of Cell Type-specific Localization
Published on: March 11, 2011
Nuclear hormone receptors in T lymphocytes
1Department of Molecular and Cell Biology, 469 LSA, University of California, Berkeley, Berkeley, CA 94720, USA. winoto@uclink4.berkeley.edu
Steroid and orphan nuclear receptors regulate immune functions. Glucocorticoid receptor, Nur77, and RORgamma are key to T lymphocyte development and effector functions.
Area of Science:
- Immunology
- Molecular Biology
- Endocrinology
Background:
- Mammalian genomes encode numerous steroid and orphan nuclear receptors.
- Several of these receptors play critical roles in immune system regulation.
- Understanding these receptors is crucial for comprehending immune responses.
Purpose of the Study:
- To review recent studies on specific nuclear receptors involved in immune function.
- To highlight the roles of the glucocorticoid receptor, Nur77, and RORgamma.
- To elucidate their impact on T lymphocyte biology.
Main Methods:
- Review of recent scientific literature.
- Analysis of studies focusing on nuclear receptor function in T cells.
- Synthesis of findings on glucocorticoid receptor, Nur77, and RORgamma.
Main Results:
- Glucocorticoid receptor is a key regulator of immune responses.
- Orphan receptors Nur77 and RORgamma are essential for T cell function.
- These receptors influence both T lymphocyte development and effector mechanisms.
Conclusions:
- Glucocorticoid receptor, Nur77, and RORgamma are vital for T lymphocyte homeostasis.
- Targeting these receptors may offer therapeutic strategies for immune-related diseases.
- Further research into these nuclear receptors will advance our understanding of immunology.
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