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Related Experiment Videos

Starving affects CDX gene expression during small intestinal development in the chick.

A Geyra1, Z Uni, O Gal-Garber

  • 1Faculty of Agriculture, Hebrew University, Rehovot, Israel, 76-100.

The Journal of Nutrition
|May 2, 2002
PubMed
Summary

Chicken homeobox genes cdxA and cdxB are crucial for small intestine development post-hatch. Their expression is linked to enterocyte proliferation and maturation, with starvation impacting their activity.

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Area of Science:

  • Developmental biology
  • Genetics
  • Animal science

Background:

  • The chicken small intestine undergoes significant development post-hatch, transitioning from yolk-based to feed-based nutrition.
  • Cdx homeobox genes are involved in embryonic patterning and cell identity, with some remaining active in the postpartum intestine.

Purpose of the Study:

  • To investigate the transcription patterns of cdxA and cdxB in the developing chicken small intestine.
  • To determine the effects of early post-hatch starvation on cdxA and cdxB expression.

Main Methods:

  • Examined cdxA and cdxB gene transcription in embryonic and post-hatch chicken small intestines.
  • Analyzed the impact of 48-hour starvation immediately post-hatch on gene expression.

Main Results:

Related Experiment Videos

  • Both cdxA and cdxB were upregulated around hatch and in proliferating enterocytes, with sustained expression post-hatch.
  • cdxA showed age-dependent distribution, with higher concentrations in mature enterocytes.
  • Starvation reduced growth, enterocyte proliferation, and cdxA/cdxB expression, which recovered upon refeeding.

Conclusions:

  • Chicken homeobox genes cdxA and cdxB are expressed throughout enterocytes during embryonic and post-hatch development.
  • cdxA may play a role in post-hatch enterocyte maturation.
  • CdxB expression was observed later in development than previously reported.