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Updated: Oct 1, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
The molecular and supramolecular structures of four 1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazolines
John Nicolson Low1, Justo Cobo, Manuel Nogueras
1Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen AB24 3UE, Scotland. jnlow111@hotmail.com
Abstract:
The supramolecular structures of the title compounds, 2-phenyl-5-p-tolyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(23)H(21)N(3), (I), 5-(4-bromophenyl)-2-phenyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(18)BrN(3), (II), 2-(4-chlorophenyl)-5-phenyl-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(18)ClN(3), (III), and 5-(4-bromophenyl)-2-(4-chlorophenyl)-1,5,6,10b-tetrahydropyrazolo[1,5-c]quinazoline, C(22)H(17)BrClN(3), (IV), are of two general types. Compounds (I), (II) and (III) form base-paired dimers via N-H.N hydrogen bonds, where (I) and (II) are isomorphous, while in (IV), there are no conventional hydrogen bonds.
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