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Related Experiment Videos

T cryptantigen activation is associated with advanced necrotizing enterocolitis.

N Hall1, E G p Ong, N Ade-Ajayi

  • 1London, England.

Journal of Pediatric Surgery
|May 3, 2002
PubMed
Summary

Thomsen-Friedenreich cryptantigen activation (TCA) is common in neonates with necrotizing enterocolitis (NEC), particularly severe cases. Screening for TCA is recommended to prevent transfusion-related hemolysis and manage NEC complications.

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Area of Science:

  • Neonatal Medicine
  • Hematology
  • Immunology

Background:

  • Necrotizing enterocolitis (NEC) poses significant risks to neonates, including potential hemolysis from blood product transfusions.
  • Thomsen-Friedenreich cryptantigen activation (TCA) is a known risk factor for hemolysis in this vulnerable population.

Purpose of the Study:

  • To determine the prevalence of TCA in neonates diagnosed with NEC.
  • To investigate the correlation between TCA and the severity of NEC.
  • To assess the relationship between TCA and patient outcomes.

Main Methods:

  • One hundred four neonates with NEC were evaluated for TCA upon admission.
  • Transfusion protocols involved packed red blood cells, low-titer anti-T fresh frozen plasma, and washed platelets for patients with TCA to mitigate hemolysis risk.

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Main Results:

  • Twenty-three infants (22%) tested positive for TCA, with 96% having stage III NEC.
  • TCA incidence was significantly higher in stage III NEC (30%) compared to stage II (4%).
  • Infants with TCA had higher rates of laparotomy (91%) and widespread disease at surgery (71%) compared to those without TCA.

Conclusions:

  • A significant association exists between TCA and advanced NEC.
  • Screening neonates with advanced NEC for TCA is crucial for identifying individuals at risk of hematologic complications.
  • Proactive management of TCA can help prevent transfusion-related adverse events in neonates with NEC.