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[Acute generalized exanthematous pustulosis due to fluconazole]
B Fabre1, B Albès, H Belhadjali
1Service de Dermatologie, CHU Purpan, Place du Dr Baylac, 31059 Toulouse Cedex.
Annales De Dermatologie Et De Venereologie
|May 4, 2002
Summary
This case study identifies fluconazole as a cause of acute generalized exanthematous pustulosis, a rare skin reaction. The patient experienced a pustular rash after fluconazole treatment for a fungal infection.
Area of Science:
- Dermatology
- Pharmacology
- Infectious Diseases
Background:
- Fluconazole is a widely used systemic triazole antifungal agent.
- Cutaneous side effects of fluconazole have been previously documented.
- This study focuses on a rare adverse drug reaction to fluconazole.
Observation:
- A 65-year-old woman developed a pustular eruption with fever and neutrophilia after three doses of fluconazole for cutaneous candidosis.
- Histological examination confirmed acute generalized exanthematous pustulosis.
- The eruption recurred without fever or neutrophilia upon re-exposure.
Findings:
- The clinical, biological, and histological findings strongly indicate fluconazole as the cause of acute generalized exanthematous pustulosis.
- The reaction was classified as certain based on EuroSCAR study criteria.
- This represents the first reported case of acute generalized exanthematous pustulosis specifically linked to fluconazole.
Implications:
- This case highlights a rare but significant adverse drug reaction to fluconazole.
- Awareness of this potential side effect is crucial for clinicians prescribing fluconazole.
- Further investigation into the mechanisms of fluconazole-induced hypersensitivity may be warranted.