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New synthesis of L-FMAU from L-arabinose

Marcos L Sznaidman¹, Merrick R Almond, Amir Pesyan

¹Division of Organic Chemistry, Triangle Pharmaceuticals Inc., RTP, North Carolina 27717, USA.

Nucleosides, Nucleotides & Nucleic Acids

|May 7, 2002

Abstract:

A new synthesis of 2'-deoxy-2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil (13, L-FMAU) was achieved in 10 steps from L-arabinose.

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