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A 27-mer tandem repeat polypeptide in bovine amelogenin: synthesis and CD spectra
1Harvard Medical School, Children's Hospital, Boston, MA 02115, USA. Renu@biofold.net
Abstract:
CD spectra of a tandem 27-mer repeat polypeptide, Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-His-Gln-Pro-Leu-Gln-Pro-Met-(Gln-Pro-Leu)4, from bovine amelogenin synthesized by standard solid-phase synthesis manifests an archtypical CD pattern of a beta-spiral structure in phosphate buffer at pH 5.2 and trifluoroethanol (TFE), CF3OH. beta-spiral structure is unique to a class of diverse proteins including amelogenins conferring unusual physicochemical properties.