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Updated: Oct 1, 2026

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
New mode of drug delivery: long term autonomous rhythmic hormone release across a hydrogel membrane
Gauri P Misra1, Ronald A Siegel
1Department of Pharmaceutics, 9-177 Weaver-Densford Hall, University of Minnesota, 308 Harvard St. S.E., Minneapolis, MN 55455, USA.
Abstract:
This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week.
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