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Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
Shinichi Uesato1, Manabu Kitagawa, Yasuo Nagaoka
1Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, 564-8680, Osaka, Japan. uesato@ipicku.kansai-u.ac.jp
Bioorganic & Medicinal Chemistry Letters
|May 7, 2002
Abstract:
Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with the 1,4-phenylene group yielded the promising HDAC inhibitors which possess a terminal bicyclic aryl amide.