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Structure and biosynthesis of human salivary mucins
A Zalewska1, K Zwierz, K Zółkowski
1Department of Pharmaceutical Biochemistry Institute of Chemistry, Białystok, Poland. kzwie@amb.ac.bialystok.pl
Acta Biochimica Polonica
|May 9, 2002
Abstract:
Human salivary glands secrete two types of mucins: oligomeric mucin (MG1) with molecular mass above 1 MDa and monomeric mucin (MG2) with molecular mass of 200-250 kDa. Monomers of MG1 and MG2 contain heavily O-glycosylated tandem repeats located at the central domain of the molecules. MG1 monomers are linked by disulfide bonds located at sparsely glycosylated N- and C-end. MG1 are synthesized by mucous cells and MG2 by the serous cells of human salivary glands.