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Updated: Oct 1, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Sensor-based measurements of the role and interactions of free radicals in cellular systems
Calum J McNeil1, Philip Manning
1Centre for Nanoscale Science and Technology, The Medical School, University of Newcastle upon Tyne, UK. calum.mcneil@ncl.ac.uk
Abstract:
Direct real-time electrochemical measurements have offered new insight into the importance of free radical interplay in a number of cell culture and in vivo models of neurodegenerative processes. This review highlights investigations carried out in this laboratory of real-time superoxide and nitric oxide free radical generation, and presents evidence of complex inter-relationships between these species. These include: a novel function for astrocytic nitric oxide synthase in controlling neuronal nitric oxide availability; and the demonstration that extracellular superoxide flux can lead to the generation of NO by glial cells. The possible consequences of these interactions are discussed.
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