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Dissolution kinetics of paracetamol single crystals.
Korlakunte V R Prasad1, Radoljub I Ristic, David B Sheen
1Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow G1 1XL, UK.
International Journal of Pharmaceutics
|May 9, 2002
Summary
The study investigated paracetamol crystal dissolution with and without p-acetoxyacetanilide (PAA). PAA increased dissolution rates of specific crystal faces, suggesting integral strain enhances solubility and dissolution.
Area of Science:
- Crystallography
- Physical Chemistry
- Materials Science
Background:
- Paracetamol (acetaminophen) is a widely used analgesic.
- Crystal morphology and growth conditions influence drug dissolution.
- Additives can modify crystal properties and dissolution behavior.
Purpose of the Study:
- To investigate the dissolution anisotropy of paracetamol crystals.
- To determine the effect of p-acetoxyacetanilide (PAA) on paracetamol dissolution rates.
- To correlate dissolution behavior with crystal strain and dissolution mechanisms.
Main Methods:
- Single crystal dissolution method in undersaturated aqueous solutions.
- Microscopic measurement of crystal face regression over time.
- Optical microscopy and X-ray topography to define dissolution mechanisms.
Main Results:
- Dissolution rates varied for different faces and crystal morphologies.
- The presence of PAA increased dissolution rates for [001] and [110] faces.
- Etch pits observed on faces suggest a 2-dimensional nucleation process.
Conclusions:
- Integral strain in paracetamol crystals increases solubility and dissolution rate.
- PAA enhances the dissolution of specific paracetamol crystal faces.
- Dissolution mechanisms involve 2-dimensional nucleation rather than dislocation control.