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Published on: August 25, 2014
Growth, developmental milestones and health problems in the first 2 years in very preterm infants compared with term
Hans Ulrich Bucher1, Christa Killer, Yvonne Ochsner
1Clinic for Neonatology, University Hospital Zurich, Switzerland. buh@fhk.usz.ch
Insights
Very preterm infants show significant growth deficits and developmental delays in their first two years. These infants also experience higher rates of hospital readmissions compared to full-term infants.
Area of Science:
- Neonatology
- Pediatric Development
- Public Health
Background:
- Infant outcomes vary significantly by region and country.
- Preterm birth before 32 weeks gestation presents unique challenges.
Purpose of the Study:
- To evaluate growth, developmental milestones, and post-discharge morbidity in very preterm infants in Switzerland.
- Compare outcomes of very preterm infants with those born at term.
Main Methods:
- National survey using questionnaires sent to parents of 456 survivors born in 1996.
- 309 very preterm infants' data matched with 309 term-born control infants.
- Data collected at corrected age of 24 months.
Main Results:
- Very preterm infants had significantly lower weight, length, and head circumference.
- Delayed milestones in spoon-feeding, cup drinking, and independent walking were observed.
- 16% of very preterm infants were unable to walk independently by 18 months, increasing cerebral palsy risk.
- 35% of very preterm infants required hospital readmission within 24 months, versus 20% of controls.
Conclusions:
- National data quantify growth retardation, developmental delay, and health issues in preterm infants.
- Early identification and intervention are crucial for improving long-term outcomes.
Unlabelled:
The outcome of very preterm infants varies widely from centre to centre and from country to country. The aim of this study was to evaluate growth, developmental milestones and post-discharge morbidity of infants born before 32 weeks of gestation in Switzerland. A questionnaire was sent to the parents of 456 survivors born in 1996. A total of 309 (68%) parents responded and their infants were matched with 309 control infants born at term. At the corrected age of 24 months, the very preterm infants had significantly lower weight (-1.0 z-scores), lower length (-1.23 z-scores), and lower head circumference (-.64 z-scores). Very preterm infants were reported to eat with a spoon later than those born at term (50% at 7.5 months corrected for prematurity versus 10 months. P<0.001), to drink later out of a cup (50% at 16.5 months versus 13.5 months, P=0.03) and to walk later independently (50% at 14.5 months versus 13.5 months, P=0.04), whereas timing of sitting unsupported was no different (50% at 7.4 months versus 7.2 months, P=0.9). Of very preterm infants, 16% were not able to walk at least three steps unsupported at 18 months after term which puts them at an increased risk for cerebral palsy. Some 35% of very preterm infants had to be readmitted to hospital during the first 24 months compared with 20% of control infants born at term (P<0.05). There was no difference between very preterm and term infants in respect to episodes of fever > 38.5 degrees C, episodes of coughing > 3 days and treatment with antibiotics.
Conclusion:
these data based on a national survey allow to quantify growth retardation, developmental delay and post-discharge health problems within the first 2 years in preterm infants born before 32(0)/7 weeks.
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