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ConsDock: A new program for the consensus analysis of protein-ligand interactions

Nicodème Paul1, Didier Rognan

  • 1Bioinformatic Group, Laboratoire de Pharmacochimie de la Communication Cellulaire, UMR CNRS 7081, Illkirch, France.

Proteins
|May 10, 2002
PubMed

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence the...