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Published on: March 14, 2014
Amphotericin B-induced hepatorenal failure in cystic fibrosis
1Department of Respiratory Paediatrics, Royal Brompton Hospital, London, United Kingdom.
Abstract:
Although nephrotoxicity is a common and well-recognized side effect of amphotericin B, hepatotoxicity is rare. We report on a 9-year-old girl with cystic fibrosis who developed fulminant renal and hepatic dysfunction following a short course of intravenous amphotericin B for a suspected aspergillus infection, although she did not have clinical evidence of invasive aspergillosis. The toxicity became apparent after changing to liposomal amphotericin. This association of renal and hepatotoxicity with liposomal amphotericin B has not previously been reported in children.
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