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Updated: May 12, 2026

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
Scatter-factor and semaphorin receptors: cell signalling for invasive growth
Livio Trusolino1, Paolo M Comoglio
1Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy. ltrusolino@ircc.unito.it
Abstract:
Malignant disease occurs when neoplastic cells abandon their primary site of accretion, cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process --metastasis--is the aberrant counterpart of a physiological programme for organ regeneration and maintenance. Scatter factors and semaphorins, together with their receptors, help to orchestrate this programme. What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?
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