Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-speed, high-sensitivity, gated surface profiling with closed-loop optical coherence topography.

Andrei V Zvyagin1, Ilos Eix, David D Sampson

  • 1The University of Western Australia, Optical + Biomedical Engineering Laboratory, Department of Electrical and Electronic Engineering, Crawley, Australia. azvyagin@ee.uwa.edu.au

Applied Optics
|May 11, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seminal Fluid Biomarkers for Early Cancer Detection: A Systematic Review.

Biomedicines·2026
Same author

Correction: Au/Mn nanodot platform for <i>in vivo</i> CT/MRI/FI multimodal bioimaging and photothermal therapy against tongue cancer.

Journal of materials chemistry. B·2026
Same author

Circulating Tumor DNA in Prostate Cancer: A Dual Perspective on Early Detection and Advanced Disease Management.

Cancers·2025
Same author

Prognostic Value of the Number of Circulating Tumor Cells in Patients with Metastatic Non-Small Cell Lung Cancer.

Micromachines·2025
Same author

Nanozyme as tumor energy homeostasis disruptor mediated ferroptosis for high-efficiency radiotherapy.

Journal of colloid and interface science·2025
Same author

Fluorescence lifetime imaging in drug delivery research.

Advanced drug delivery reviews·2025
Same journal

Multifunctional reconfigurable terahertz metasurface based on vanadium dioxide phase transition: achieving broadband absorption and efficient polarization conversion.

Applied optics·2026
Same journal

High-Q-factor electromagnetically induced transparency utilizing quasi-bound states in the continuum in an all-dielectric terahertz metasurface.

Applied optics·2026
Same journal

Automated stitching interferometry for high-precision metrology of X-ray mirrors.

Applied optics·2026
Same journal

Experimental demonstration of an approach to designing a metal-dielectric DBR resonant cavity structure.

Applied optics·2026
Same journal

High-precision wavefront reconstruction from a single-shot interferogram using a physics-driven hybrid feature calibration network.

Applied optics·2026
Same journal

Ultra-high-Q Fano resonance based on coupled topological corner states in Kagome photonic crystals.

Applied optics·2026
See all related articles

We developed a new surface profiling method called closed-loop optical coherence topography. This technique enables high-speed, sub-wavelength tracking of macroscopic surfaces, ideal for biological applications.

Area of Science:

  • Biomedical optics
  • Surface metrology
  • Optical engineering

Background:

  • Accurate surface profiling is crucial for various scientific and medical applications.
  • Existing techniques may lack the speed, resolution, or specificity required for certain surfaces, especially in vivo.
  • Low-coherence interferometry offers non-contact measurement capabilities.

Purpose of the Study:

  • To introduce and demonstrate a novel surface profiling technique: closed-loop optical coherence topography (CL-OCT).
  • To achieve sub-wavelength resolution tracking of macroscopic surfaces in real-time.
  • To enable high-speed, non-invasive surface characterization, particularly for biological tissues.

Main Methods:

  • Developed a scanning beam, servo-locked variation of low-coherence interferometry.

Related Experiment Videos

  • Implemented a micrometer-scale coherence gate to isolate surface signals.
  • Integrated controlling electronics for direct surface profile output, minimizing computational overhead.

    • Main Results:

    • Demonstrated sub-wavelength resolution tracking of macroscopic surfaces.
    • Achieved high-speed surface profiling with minimal real-time computational requirements.
    • Successfully suppressed signals from non-surface structures using the coherence gate.

    Conclusions:

    • Closed-loop optical coherence topography (CL-OCT) is a novel and effective technique for surface profiling.
    • The method's speed, resolution, and specificity make it suitable for real-time in vivo applications.
    • CL-OCT offers a promising tool for macroscopic biological surface analysis.