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The total eosinophil count and adrenal function in asthmatic children
Annals of Allergy
|December 1, 1975
Summary
Asthmatic children with normal plasma cortisol levels showed significant decreases in total eosinophil count (TEC). Low cortisol levels correlated with minimal TEC changes, indicating a link between cortisol and eosinophil response in asthma.
Area of Science:
- Pediatric Pulmonology
- Endocrinology
- Immunology
Background:
- Asthma is a chronic respiratory disease characterized by airway inflammation.
- Plasma cortisol levels and total eosinophil count (TEC) are key biomarkers in inflammatory conditions.
- The relationship between cortisol and eosinophil dynamics in pediatric asthma requires further elucidation.
Purpose of the Study:
- To investigate the correlation between morning plasma cortisol levels and changes in TEC in children with asthma.
- To determine if cortisol levels predict the magnitude of TEC reduction following an early morning blood draw.
Main Methods:
- A cohort of 36 children diagnosed with asthma was studied.
- Plasma cortisol levels were measured at 8:00 a.m.
- Total eosinophil count (TEC) was assessed at 8:00 a.m. and 9:30 a.m. to determine percentage change.
Main Results:
- Children with low plasma cortisol levels (
- Conversely, 78% of children with normal plasma cortisol levels demonstrated a significant TEC decrease (>15%).
- All children experiencing a >15% TEC decrease had normal cortisol levels.
Conclusions:
- Normal morning plasma cortisol levels are associated with a substantial reduction in TEC in asthmatic children.
- Low cortisol levels may indicate a blunted eosinophil response in pediatric asthma.
- Cortisol levels appear to be a relevant factor in modulating eosinophil activity in asthmatic children.