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The total eosinophil count and adrenal function in asthmatic children

M Z Blumberg, J M Buckley

    Annals of Allergy
    |December 1, 1975
    PubMed

    Insights

    Asthmatic children with normal plasma cortisol levels showed significant decreases in total eosinophil count (TEC). Low cortisol levels correlated with minimal TEC changes, indicating a link between cortisol and eosinophil response in asthma.

    Area of Science:

    • Pediatric Pulmonology
    • Endocrinology
    • Immunology

    Background:

    • Asthma is a chronic respiratory disease characterized by airway inflammation.
    • Plasma cortisol levels and total eosinophil count (TEC) are key biomarkers in inflammatory conditions.
    • The relationship between cortisol and eosinophil dynamics in pediatric asthma requires further elucidation.

    Purpose of the Study:

    • To investigate the correlation between morning plasma cortisol levels and changes in TEC in children with asthma.
    • To determine if cortisol levels predict the magnitude of TEC reduction following an early morning blood draw.

    Main Methods:

    • A cohort of 36 children diagnosed with asthma was studied.
    • Plasma cortisol levels were measured at 8:00 a.m.
    • Total eosinophil count (TEC) was assessed at 8:00 a.m. and 9:30 a.m. to determine percentage change.

    Main Results:

    • Children with low plasma cortisol levels (
    • Conversely, 78% of children with normal plasma cortisol levels demonstrated a significant TEC decrease (>15%).
    • All children experiencing a >15% TEC decrease had normal cortisol levels.

    Conclusions:

    • Normal morning plasma cortisol levels are associated with a substantial reduction in TEC in asthmatic children.
    • Low cortisol levels may indicate a blunted eosinophil response in pediatric asthma.
    • Cortisol levels appear to be a relevant factor in modulating eosinophil activity in asthmatic children.

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