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Chemoprevention of oral cancer by green tea

Stephen D Hsu1, Baldev B Singh, Jill B Lewis

  • 1Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta, USA.

General Dentistry
|May 15, 2002
PubMed

Insights

Green tea polyphenols selectively induce apoptosis in oral cancer cells, not normal cells. This suggests green tea

Area of Science:

  • Oncology
  • Molecular Biology
  • Nutritional Science

Background:

  • Green tea consumption is widespread.
  • Green tea polyphenols exhibit anti-cancer properties.
  • Mechanisms of selective apoptosis induction in cancer cells are not fully understood.

Purpose of the Study:

  • To investigate the effects of green tea extracts and polyphenols on normal human keratinocytes and oral carcinoma cells.
  • To elucidate the mechanisms behind selective apoptosis induction in oral cancer cells.

Main Methods:

  • Cell growth and invasion assays.
  • Apoptosis assays.
  • Analysis of normal human keratinocytes and oral carcinoma cells treated with green tea constituents.

Main Results:

  • Green tea and its constituents selectively induced apoptosis in oral carcinoma cells.
  • (-)-epigallocatechin-3-gallate (EGCG) inhibited oral cancer cell growth and invasion.
  • Differential responses correlated with the induction of p57, a cell cycle regulator.

Conclusions:

  • Green tea polyphenols may prevent oral cancer by inducing apoptosis in cancer cells via p57.
  • Normal cells may utilize a p57-mediated survival pathway, evading apoptosis.
  • Regular green tea consumption may offer chemopreventive benefits against oral cancer.

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