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Diffuse metabolic abnormalities in reversible posterior leukoencephalopathy syndrome
Florian S Eichler1, Paul Wang, Robert J Wityk
1Department of Neurogenetics, The Johns Hopkins University, Baltimore, MD, USA.
AJNR. American Journal of Neuroradiology
|May 15, 2002
Summary
Proton MR spectroscopic imaging revealed metabolic changes in reversible posterior leukoencephalopathy syndrome (RPLS). These abnormalities normalized over time, suggesting this technique aids RPLS diagnosis and pathophysiology study.
Area of Science:
- Neurology
- Radiology
- Biochemistry
Background:
- Reversible posterior leukoencephalopathy syndrome (RPLS) is a neurological condition.
- Understanding its metabolic underpinnings is crucial for diagnosis and management.
Observation:
- Proton MR spectroscopic imaging (sPMI) was used to examine two cases of RPLS.
- Metabolic abnormalities were observed in both normal and abnormal appearing brain regions on MRI.
Findings:
- Widespread metabolic alterations included elevated choline and creatine, and reduced N-acetylaspartate.
- In one patient, sPMI follow-up showed normalization of metabolite levels within two months.
Implications:
- sPMI may be a valuable tool for diagnosing RPLS.
- This technique can help investigate the pathophysiology of RPLS.