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Prurigo nodularis. Histological and electron microscopical study.

E J Feuerman, M Sandbank

    Archives of Dermatology
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    Prurigo nodularis involves nerve tissue changes, including thickened nerve fibers and Schwann cell abnormalities. These findings suggest axon swelling may be a general response to skin injury in this chronic condition.

    Area of Science:

    • Dermatology
    • Neuropathology

    Background:

    • Prurigo nodularis is a chronic inflammatory skin condition characterized by intense itching and excoriated nodules.
    • Understanding the underlying pathophysiology is crucial for developing effective treatments.

    Observation:

    • A case study of a middle-aged woman with a 15-year history of prurigo nodularis was examined.
    • Histological and electron microscopy revealed significant alterations in skin nerve tissue.

    Findings:

    • Nodules showed thickened nerve fibers with numerous Schwann cells, extending to the dermoepidermal junction.
    • Electron microscopy identified lesions in Schwann cells (lucent cytoplasm, few mitochondria, absent endoplasmic reticulum, vacuoles) and axons.
    • Axons varied in diameter; large axons were empty, while small ones contained neurofilaments. Each Schwann cell enveloped multiple axons.

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    Implications:

    • The observed axon swelling is hypothesized to be a non-specific reaction to nerve injury.
    • These neuropathological findings contribute to the understanding of prurigo nodularis pathogenesis.
    • Further research may elucidate specific mechanisms driving these nerve changes in prurigo nodularis.