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Updated: Jul 17, 2026
10:40
Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
Published on: September 10, 2013
Emerging concepts of nucleolar assembly
Danièle Hernandez-Verdun1, Pascal Roussel, Jeannine Gébrane-Younès
1CNRS, Université Paris VI, Université Paris VII, Institut Jacques Monod, 2 place Jussieu, 75251 Paris Cedex 05, France. dhernand@ccr.jussieu.fr
Journal of Cell Science
|May 15, 2002
Summary
The nucleolus, vital for ribosome biogenesis and cell survival, is dynamically assembled during the cell cycle and embryogenesis. New research reveals insights into its assembly control and nuclear organization integration.
Area of Science:
- Cell Biology
- Molecular Biology
- Genetics
Background:
- The nucleolus is a key nuclear domain responsible for ribosome biogenesis.
- It plays a crucial role in cell survival by regulating processes like cell cycle progression and gene silencing.
Purpose of the Study:
- To provide an integrated view of nucleolar assembly dynamics during the cell cycle and embryogenesis.
- To explore new ideas regarding cell cycle control of nucleolar assembly and nuclear organization.
Main Methods:
- Investigated nucleolar assembly dynamics.
- Analyzed cell cycle control mechanisms.
- Examined the role of RNA processing machinery and precursor ribosomal RNAs.
Main Results:
- Recent investigations offer an integrated view of nucleolar assembly dynamics.
- New insights generated on cell cycle control, RNA processing machinery delivery, and prenucleolar body formation.
- Identified the role of precursor ribosomal RNAs in stabilizing nucleolar machinery.
- Demonstrated cooperative interactions between chromosome territories in completing nucleolar assembly.
Conclusions:
- Nucleolar assembly is a dynamic process influenced by cell cycle and embryogenesis.
- Understanding nucleolar dynamics opens new research avenues in nuclear organization and function integration.
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