Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enteric nervous system: development and developmental disturbances--part 1.

Donald Newgreen1, Heather M Young

  • 1Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, 3052, Victoria, Australia.

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
|May 15, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strengthening the Future of Nursing Education.

Research in gerontological nursing·2026
Same author

Caregivers with poorer health are less likely to engage in an intervention to prepare for their own health care emergency.

The Gerontologist·2026
Same author

Rural Aging and Health Equity.

Research in gerontological nursing·2026
Same author

Charting the course: The imperative for creative reimagining among nurse scientists in an era of unprecedented threat.

Nursing outlook·2026
Same author

Preparing the next generation of nurse leaders and innovators: Betty Irene Moore Fellowship overview and special issue introduction.

Nursing outlook·2026
Same author

Empowering nursing excellence: How liberation capital can elevate innovative ideas.

Nursing outlook·2026
Same journal

Rhabdomyomatous Mesenchymal Hamartoma With Prominent Folliculosebaceous Hyperplasia in an Infant's Philtrum: A Case Report.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Heterotopic Salivary Gland in the Rectum Associated with Lumbosacral Lipomeningocele: A Dual Developmental Anomaly.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Assessing Normal Histologic Patterns in Perinatal Tissue: A Practical Guide.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Perinatal Autopsy Guidance for the General Pathologist.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

The Placenta: Identifying Normal.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same journal

Ancillary and Advanced Techniques for the Postmortem Examination.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
See all related articles

This review explores genetic and molecular factors influencing enteric nervous system (ENS) formation and its disorders, like Hirschsprung

Area of Science:

  • Developmental Biology
  • Genetics
  • Neuroscience

Background:

  • The enteric nervous system (ENS) is crucial for gastrointestinal function.
  • Defects in ENS development lead to congenital disorders such as Hirschsprung's disease (HSCR).
  • Understanding the genetic and molecular basis of ENS formation is vital for diagnosing and treating these conditions.

Purpose of the Study:

  • To review the genetic, molecular, and cell biological mechanisms underlying early embryonic ENS development.
  • To synthesize current knowledge on the genetic underpinnings of ENS developmental defects, focusing on HSCR and intestinal neuronal dysplasia type B (INDB).
  • To discuss the known genes involved in ENS formation and identify areas for future research.

Main Methods:

  • Literature review and synthesis of existing research on ENS development.

Related Experiment Videos

  • Analysis of genetic mutations and deletions associated with ENS abnormalities in human and animal models.
  • Focus on key signaling pathways, including GDNF and ET-3, and transcription factors.

    • Main Results:

    • Identified critical genes involved in ENS development, with mutations causing HSCR-like phenotypes in animal models.
    • Highlighted the significance of the GDNF and ET-3 signaling systems in ENS formation.
    • Noted that a substantial portion of HSCR cases remain genetically unexplained, indicating undiscovered genes.

    Conclusions:

    • Genetic and molecular factors play a pivotal role in the proper development of the enteric nervous system.
    • Mutations in specific genes, particularly those in the GDNF and ET-3 pathways, are strongly linked to ENS disorders.
    • Further research is needed to identify additional genes involved in ENS development to improve understanding and treatment of related diseases.