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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Serum levels of selected adhesion molecules in patients with coronary artery disease

Katarzyna Mizia-Stec1, Barbara Zahorska-Markiewicz, Tadeusz Mandecki

  • 1Department of Pathiophysiology, Department of Cardiology, Silesian University School of Medicine, Ziolowa Street 45/47, 40 635, Katowice, Poland. biboch@slam.katowice.pl

International Journal of Cardiology
|May 15, 2002
PubMed

Insights

Stable angina patients show normal adhesion molecule levels, while unstable angina patients have elevated sP-selectin and sVCAM-1. Exercise increases sE-selectin in stable angina, indicating endothelial response.

Area of Science:

  • Cardiovascular biology
  • Immunology
  • Biochemistry

Background:

  • Adhesion molecules are implicated in the inflammatory processes of atherosclerosis.
  • These molecules may play a role in the pathogenesis of both stable and unstable angina.

Purpose of the Study:

  • To investigate serum levels of soluble adhesion molecules in patients with stable and unstable angina.
  • To compare these levels with healthy controls and assess changes post-exercise or post-event.

Main Methods:

  • Studied 59 coronary artery disease patients (27 stable angina, 32 unstable angina) and 20 healthy controls.
  • Measured serum levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1), Vascular Cell Adhesion Molecule 1 (sVCAM-1), sE-selectin, and sP-selectin.
  • Measurements were taken pre/post-treadmill test for stable angina and controls, and at 6, 24, 48 hours post-chest pain for unstable angina.

Main Results:

  • Baseline adhesion molecule levels did not differ between stable angina patients and controls.
  • Post-exercise sE-selectin levels were significantly higher in stable angina patients compared to baseline and controls.
  • Unstable angina patients exhibited significantly elevated serum sP-selectin and sVCAM-1 compared to stable angina and control groups.

Conclusions:

  • Serum adhesion molecule levels are comparable in stable angina patients and healthy individuals.
  • Increased sE-selectin post-exercise suggests an endothelial response to physical stress.
  • Elevated sP-selectin and sVCAM-1 in unstable angina indicate heightened platelet and leukocyte activation.
Abstract

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