[Morphological changes in the kidney in acetic acid poisoning]

The kidneys of 118 patients who had perished because of vinegar acid poisoning were studied morphologically in periods from 2 hours to 26 days. Comparisons of morphological findings and clinical patterns and different methods of treatment of this kind of intoxication were made. Lesions of the kidneys in vinegar acid poisoning were similar to those in acute hemoglobinuric nephrosis. A characteristic morphological feature of acute renal insufficiency was ruptures of distal tubules. Some peculiar features of the morphology of the kidneys in acute renal insufficiency associated with treatment methods (stimulation of osmotic diuresis, hemodialysis and peritoneal dialyses) were revealed. It was established that early intensive complex therapy changed essentially the morphological picture of acute hemoglobinuric nephrosis and could prevent irreversible lesions--ruptures of distal tubules.