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The role of innate mediators in inflammatory response
1Department of Immunology and Bacteriology, University of Glasgow, G11 6NT, UK. fyllh@clinmed.gla.ac.uk
Molecular Immunology
|May 16, 2002
Abstract:
Cytokines produced by innate immune response can profoundly influence the subsequent adaptive immunity. IL-15 and -18 are two of several mediators produced by macrophages that perform such a function. Here we present recent data mainly from our own laboratory illustrating the important role of IL-15 and -18 in the induction and perpetuation of chronic inflammation during experimental and clinical rheumatoid synovitis.