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Postoperative hypoglycaemic coma associated with chlorpropamide.

R J Schen, A S Khazzam

British Journal of Anaesthesia

|August 1, 1975

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A patient on chlorpropamide for diabetes experienced hypoglycaemic coma after surgery for a perforated gastric ulcer. This highlights a critical drug interaction risk during surgical emergencies.

Area of Science:

Endocrinology
Gastroenterology
Surgical Complications

Background:

Diabetes mellitus management with oral hypoglycemic agents.
Chlorpropamide as a first-generation sulfonylurea for type 2 diabetes.
Perforated gastric ulcer as a surgical emergency.

Observation:

A 72-year-old male patient with a history of diabetes mellitus.
Treatment regimen included chlorpropamide.
Underwent emergency surgery for a perforated gastric ulcer.

Findings:

Post-operative hypoglycaemic coma developed.
Potential link between chlorpropamide and post-operative metabolic complications.
Sustained glucose-lowering effect of chlorpropamide contributing to severe hypoglycemia.

Related Experiment Videos

Implications:

Need for careful medication review in diabetic patients undergoing surgery.
Risk of severe hypoglycemia with sulfonylureas in perioperative settings.
Importance of monitoring glucose levels closely in patients treated with chlorpropamide post-operatively.