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Updated: Aug 19, 2026

Generation of Organ-conditioned Media and Applications for Studying Organ-specific Influences on Breast Cancer Metastatic Behavior
Published on: June 13, 2016
Prognostic factors in breast cancer: current and new predictors of metastasis
D F Hayes1, C Isaacs, V Stearns
1Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor 48109-0942, USA. hayesdf@umich.edu
Abstract:
Decisions regarding the use of adjuvant therapy for breast cancer are strongly influenced by the risk of disease recurrence and death. These risks are now determined by examining the currently recognized breast cancer prognostic factors, including clinical stage, axillary nodal status, tumor size and grade, hormone receptor status, and presence of lymphovascular involvement. Newer factors are being evaluated in an attempt to more precisely define disease-related prognosis. This paper provides an overview of issues that need to be considered when analyzing studies of prognostic factors as well as a review of the currently recognized and the newer candidate prognostic factors.
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