Related Experiment Video
Updated: Aug 12, 2026

Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
[Effects of glycyrrhetic acid on transmitter secretion]
O N Ibodullaev1, M I Asrarov, D Kalikulov
1Institute of Physiology and Biophysics of the Uzbek Acad. Sci., Tashkent, 700095, 1 Niyazov St.
Abstract:
The investigation of the effects of glycyrrhetic acid on spontaneous secretion of transmitter from neurotermination of the frog neuromuscular synapses showed that this substance, unlike glycyrrhizic acid, increased the frequency and amplitude of m. e. p. p. in a dose-dependent manner. The effect of glycyrrhetic acid is observed in calcium-free solution which may indicate ability of glycyrrhetic acid to mobilize calcium from inner cell pools. The effects of glycyrrhetic acid, in particular increasing the frequency of the m. e. p. p., testify that glycyrrhetic acid acts on the level of presynaptic membrane.
Related Concept Videos
Excitatory and Inhibitory Effects of Neurotransmitters
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
GPCRs Regulate Adenylyl Cylase Activity
Two...
Neurochemical Transmission: Sites of Drug Action
Drugs Affecting Neurotransmitter Release or Uptake
Chemical Synapses
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...

