Construction, simulation, clinical application and sensitivity analysis of a human left ventricular control system...

A regulated left ventricular dynamics model is presented which involves interaction of the dynamics of the left ventricular and circulatory systems and their regulation by the central nervous system. On-line human parametric stimulation (parameter estimation) and consequential prognostic implications (based on parametric values) are demonstrated. Model responses to stimulated physiologic stresses help delineate tolerances of subjects. In order to have an estimate of the reliability of the model, the sensitivity of the model's responses to changes in the values of its intrinsic parameters is assessed. Also determined is the extent to which errors in measuring the pressure affect the calculated values of the model's responses to changes in the values of its intrinsic parameters is assessed. Also determined is the extent to which errors in measuring the pressure affect the calculated values of the model's simulation parameters and subsequently influence the values of other diagnostically useful variables (such as contractility, oxygen consumption rate, heart rate), when the model is used to determine the limiting physiological stress sustainable by the subject. A comparison of the model's composition with those of other similar cardio-circulatory models is included.