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Influence of vitamin B1 on sanazole activity under irradiation. A study in vitro
Edith Heinrich1, Nikola Getoff
1Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Austria.
Anticancer Research
|May 17, 2002
Abstract:
The effect of vitamin B1 (thiamine) on sanazole (AK-2123) efficiency was investigated in vitro under irradiation, using E. coli bacteria (AB 1157) as a model. In order to get a deeper insight into the reaction mechanisms, the experiments were performed in media saturated with argon, air or N20. In the first case vitamin B1 acts as a cytostatic, but in the presence of air or N20 it shows strongly pronounced antioxidant action and leads to an essential increase of sanazole efficiency.