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[MG7 expression in helicobacter pylori-related gastric diseases]
Dongli Guo1, Ming Dong, Yuan Yuan
1Cancer Institute of China Medical University, Shenyang 110001, China.
Objective:
To determine the influence of Helicobacter pylori (H. pylori) on gastric cancer-related antigen MG7 expression.
Methods:
The H. pylori infection and the expression level of antigen MG7 in gastric mucosa were determined by HE stain, PCR, ELISA and immunohistochemistry in 291 patients with H. pylori-related conditions, among whom 34 were followed-up.
Results:
No significant difference was found between H. pylori-negative and H. pylori-positive intestinal metaplasia, atrophic gastritis and dysplasia of gastric epithelium in positive rate of antigen MG7 expression. There was significant difference between H. pylori-negative and H. pylori-positive superficial gastritis in the positive rate of MG7 expression (P < 0.05). During follow-up, one of 3 H. pylori-negative cases turned to be H. pylori-positive, and its MG7 expression turned to be higher at the same time. Three of 31 H. pylori-positive patients were discovered as having early gastric cancer, among whom one with antigen MG7 expression (+ + +) was found to have a reduced Mg7 expression accompanied with H. pylori eliminutied after operation.
Conclusion:
There is correlationship between H. pylori infection and MG7 expression in superficial gastritis. Although the MG7-positive lesions with H. pylori infection shows a benign nature in morphology, they also have the potential risk of developing into gastric cancer. Therefore, they should be followed up, during which special attention should be paid to patients with increased MG7 expression.
Insights
Helicobacter pylori infection correlates with MG7 antigen expression in superficial gastritis. While lesions appear benign, increased MG7 expression signals potential gastric cancer risk, necessitating close patient follow-up.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Helicobacter pylori (H. pylori) is a known risk factor for gastric cancer.
- MG7 antigen is a marker associated with gastric cancer.
- Understanding the interplay between H. pylori and MG7 expression is crucial for early detection and prevention of gastric cancer.
Purpose of the Study:
- To investigate the relationship between H. pylori infection and the expression of the gastric cancer-related antigen MG7.
- To assess the diagnostic and prognostic value of MG7 expression in H. pylori-infected patients.
Main Methods:
- A cohort of 291 patients with H. pylori-related conditions were analyzed.
- H. pylori infection and MG7 antigen expression were assessed using HE stain, PCR, ELISA, and immunohistochemistry.
- A subset of 34 patients underwent follow-up evaluations.
Main Results:
- A significant positive correlation was observed between H. pylori infection and MG7 expression in superficial gastritis (P < 0.05).
- No significant difference in MG7 expression was found in intestinal metaplasia, atrophic gastritis, or dysplasia between H. pylori-negative and -positive groups.
- Follow-up revealed one case transitioning from H. pylori-negative to positive with increased MG7 expression; one patient with high MG7 expression developed early gastric cancer after H. pylori eradication.
Conclusions:
- H. pylori infection is linked to MG7 expression in superficial gastritis.
- MG7-positive lesions in H. pylori-infected individuals, despite benign morphology, indicate a potential risk for gastric cancer development.
- Regular monitoring and attention to elevated MG7 expression are recommended for patients with H. pylori infection to mitigate gastric cancer risk.