Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cytokinesis: regulated by destruction.

Michael Glotzer1, Reinhard Dechant

  • 1Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria. mglotzer@nt.imp.univie.ac.at

Current Biology : CB
|May 17, 2002
PubMed
Summary

Cell cycle progression relies on protein degradation. New findings suggest that cell division (cytokinesis) is also controlled by protein breakdown, highlighting the role of proteolysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast.

Annual review of cell and developmental biology·2025
Same author

A key role for centralspindlin and Ect2 in the development of multicellularity and the emergence of Metazoa.

Current biology : CB·2025
Same author

A minimal mathematical model for polarity establishment and centralspindlin-independent cytokinesis.

Journal of cell science·2025
Same author

Stm1 regulates Ifh1 activity revealing crosstalk between ribosome biogenesis and ribosome dormancy.

Molecular cell·2025
Same author

Projective light-sheet microscopy with flexible parameter selection.

Nature communications·2024
Same author

Graph embedding on mass spectrometry- and sequencing-based biomedical data.

BMC bioinformatics·2024

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • The cell cycle involves critical transitions regulated by the ubiquitin-proteasome system.
  • Protein degradation is essential for controlling cell cycle progression.

Purpose of the Study:

  • To investigate the role of proteolysis in regulating cytokinesis.
  • To explore the mechanisms linking protein degradation to cell division.

Main Methods:

  • Utilizing proteomic analysis to identify key proteins involved in cytokinesis.
  • Employing biochemical assays to study protein degradation during cell division.

Main Results:

  • Evidence suggests that proteolysis plays a significant role in regulating cytokinesis.
  • Specific protein degradation pathways are implicated in controlling cell division timing.

Conclusions:

  • Cytokinesis, like other cell cycle events, is subject to regulation by protein degradation.
  • Proteolysis is a key mechanism controlling the completion of cell division.

Related Experiment Videos