Related Experiment Video
Updated: Sep 15, 2025

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Along the Trajectory to Understanding Cellular Aging: More Lessons from Yeast
Kiyan Shabestary1, Reinhard Dechant1, Daniel E Gottschling1
1Calico Life Sciences LLC, South San Francisco, California, USA;
None:
Aging is a universal biological phenomenon that affects all biological systems. It is characterized by the inability to remain in a balanced physiological state, leading to a functional decline of the organism and, in metazoa, an increased risk of age-related diseases. Identifying causal drivers of aging is a major challenge at the cellular level, but in the model organism Saccharomyces cerevisiae, recent technical advances enabling the full observation of its replicative lifespan have revealed a heterogeneous aging process characterized by unique temporal and functional dependencies between cellular subprocesses. Specifically, cellular aging progresses through different trajectories, representing successive stages of homeostatic loss throughout the organism's life. In this perspective, we review the latest cellular principles as learned from S. cerevisiae that are providing a better understanding of how cellular aging progresses in metazoa.
Related Concept Videos
Mitochondria
Yeast Signaling
Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Replication in Eukaryotes
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
The Effect of Aging on Tissues
Cells Coordinate Growth and Proliferation

