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GTPase signaling: bridging the GAP between ARF and Rho
Lorraine C Santy1, James E Casanova
1Department of Cell Biology, University of Virginia, Health Sciences Center, P.O. Box 800732, Charlottesville, Virginia 22908-0732, USA.
Current Biology : CB
|May 17, 2002
Abstract:
Membrane traffic and actin cytoskeleton dynamics are intimately linked, and GTPases of the Rho and ARF families may work together to regulate both. Recent studies have identified a family of GTPase activating proteins (GAPs) that contain both ARF-GAP and Rho-GAP domains, providing the first direct link between these two signaling pathways.