Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimal sequencing by hybridization in rounds.

Alan M Frieze1, Bjarni V Halldórsson

  • 1Department of Mathematical Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|May 23, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequence Diversity Lost in Early Pregnancy.

Obstetrical & gynecological survey·2026
Same author

African-ancestry-specific variant IKKβ p.Glu502Lys confers high lupus risk.

Nature genetics·2025
Same author

Sequence diversity lost in early pregnancy.

Nature·2025
Same author

Missense variants in FRS3 affect body mass index in populations of diverse ancestries.

Nature communications·2025
Same author

Complete human recombination maps.

Nature·2025
Same author

Gene-based burden tests of rare germline variants identify six cancer susceptibility genes.

Nature genetics·2024
Same journal

Mosquito Species and Gender Identification System Based on Artificial Intelligence and Image Processing Methods.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

GMSA: A Graph Matching and Point Cloud Registration-Based Method for Spatial Transcriptomics Data Alignment.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Investigations on Multiple Protein Scaffold Filling.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Cell Type Prediction for Single-Cell RNA Sequencing Utilizing Unsupervised Domain Adaptation and Semi-Supervised Learning.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

PPIGAN: Prediction of Protein-Protein Interactions Using Generative Adversarial Networks.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Deep Structure-Enhanced Cell Clustering Model for Single-Cell RNA Sequencing Data.

Journal of computational biology : a journal of computational molecular cell biology·2026
See all related articles

This study introduces a novel algorithm for DNA sequencing by hybridization (SBH). The method efficiently sequences long DNA strings using multiple small SBH chips, approaching theoretical probe limits.

Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology

Background:

  • Sequencing by hybridization (SBH) is a DNA sequencing method utilizing oligonucleotide probes.
  • Current SBH methods face challenges in efficiently sequencing long DNA strands.

Purpose of the Study:

  • To develop an improved algorithm for sequencing long DNA strings using SBH.
  • To optimize the number of probes required for DNA sequencing.

Main Methods:

  • The study proposes an algorithm building on Margaritis and Skiena's work.
  • The algorithm employs a series of small sequencing by hybridization chips.
  • A combinatorial approach is used to reconstruct the DNA sequence from probe data.

Main Results:

  • The developed algorithm effectively sequences long DNA strings.

Related Experiment Videos

  • The method significantly reduces the number of probes needed compared to traditional approaches.
  • The probe count approaches the information-theoretical lower bound.

    • Conclusions:

    • The proposed SBH algorithm offers an efficient and probe-optimized method for DNA sequencing.
    • This approach advances the capabilities of sequencing by hybridization for complex genomic applications.