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Localized pure ground-glass opacity on high-resolution CT: histologic characteristics
Ryu Nakajima1, Tomoyuki Yokose, Ryutaro Kakinuma
1Pathology Division, National Cancer Center Research Institute East, Chiba, Japan.
Journal of Computer Assisted Tomography
|May 23, 2002
Summary
Localized pure ground-glass opacity (LPGGO) on CT scans can include invasive lung cancer. Histologic analysis of LPGGO lesions revealed malignancy in 60% of cases, underscoring the need for pathological examination.
Area of Science:
- Pulmonary Medicine
- Thoracic Pathology
- Diagnostic Imaging
Background:
- Localized pure ground-glass opacity (LPGGO) is a finding on high-resolution CT (HRCT).
- Distinguishing benign from malignant LPGGO is crucial for patient management.
- Consolidation is often absent in LPGGO, complicating diagnosis.
Purpose of the Study:
- To histologically characterize localized pure ground-glass opacity (LPGGO) lesions.
- To correlate HRCT findings with histopathologic diagnoses in LPGGO.
- To assess the prevalence of malignancy within LPGGO.
Main Methods:
- Retrospective analysis of 20 surgically resected LPGGO lesions.
- Review of HRCT images and corresponding histopathologic findings.
- Correlation of lesion diameter and nonaerogenous components.
Main Results:
- LPGGO lesions ranged from 2-24 mm in diameter.
- Histopathology revealed fibrosis (15%), atypical adenomatous hyperplasia (25%), bronchioloalveolar carcinoma (50%), and adenocarcinoma with stromal invasion (10%).
- Nonaerogenous components, indicative of malignancy, were present in 75% of lesions.
Conclusions:
- A significant proportion of LPGGO lesions harbor malignancy, including invasive adenocarcinoma.
- Pathologic examination is essential for accurate diagnosis of LPGGO.
- Early detection and characterization of LPGGO improve lung cancer outcomes.