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Chromosome-encoded class D beta-lactamase OXA-23 in Proteus mirabilis
R Bonnet1, H Marchandin, C Chanal
1Laboratoire de Bactériologie, Faculté de Médecine, 63001 Clermont-Ferrand Cedex, France. Richard.Bonnet@u-clermont1.fr
Antimicrobial Agents and Chemotherapy
|May 23, 2002
Abstract:
Ten nonrepetitive Proteus mirabilis isolates, which were collected over 4 years (1996 to 1999) at the teaching hospital of Clermont-Ferrand, France, produced class D carbapenemase OXA-23. MICs of imipenem were 0.25 to 0.5 microg/ml for these clinical isolates. Molecular typing revealed that the 10 P. mirabilis isolates originated from the same clonal strain. Hybridization of I-CeuI-generated chromosome fragments with a bla(OXA-23) probe showed that the gene was chromosome encoded in the P. mirabilis strain.