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Updated: Jul 12, 2026
06:38
Induction of Ocular Surface Inflammation and Collection of Involved Tissues
Published on: August 4, 2022
Tissue adhesive and postoperative allergic meningitis.
Akihiko Kitoh1, Yaeno Arima, Chikako Nishigori
1Department of Dermatology, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, 606-8507, Kyoto, Japan. kichu@kuhp.kyoto-u.ac.jp
Lancet (London, England)
|May 22, 2002
Summary
A patient developed allergic meningitis after surgery due to a tissue adhesive. Patch testing identified methyl-2-cyanoacrylate as the likely allergen, highlighting risks of cyanoacrylate adhesives in surgical procedures.
Area of Science:
- Neurosurgery
- Allergology
- Neurology
Background:
- Cyanoacrylate adhesives are widely used in surgical procedures, including intracranial aneurysm repair and skin wound closure.
- Postoperative complications can arise from foreign substances used during surgery.
Observation:
- A 61-year-old woman presented with fever, neck stiffness, and cerebrospinal fluid eosinophilia following intracranial aneurysm surgery.
- These symptoms raised suspicion of allergic meningitis potentially caused by a surgical material.
Findings:
- Patch testing was conducted using suspected allergens.
- A positive reaction was observed for methyl-2-cyanoacrylate, the primary component of the Biobond tissue adhesive used in the patient's surgery.
Implications:
- Methyl-2-cyanoacrylate, a common surgical adhesive, may trigger allergic meningitis.
- This finding necessitates careful consideration of cyanoacrylate-based tissue adhesives in patients with postoperative neurological symptoms.
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