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Electrochemiluminescence Assays for Human Islet Autoantibodies
Published on: March 23, 2018
Distinct IA-2 autoantibody epitope recognition between childhood-onset and adult-onset type 1 diabetes
Eiji Kawasaki1, Yasunori Sera, Norio Abiru
1The First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852-8501, Japan. f1196@cc.nagasaki-u.ac.jp
Abstract:
Different autoimmune mechanisms may be involved in childhood- and adult-onset type 1 diabetes. Our aim was to explore the differences in IA-2 autoantibody epitope recognition between childhood- and adult-onset type 1 diabetes. Therefore, in vitro synthesized radiolabeled IA-2ic (amino acid 601-979), IA-2JM (amino acid 557-629), and IA-2PTP (amino acid 630-979) were used to analyze the IA-2 autoantibody epitope specificities in 93 patients with new-onset type 1 diabetes. Among 93 patients with type 1 diabetes the prevalences of autoantibodies to GAD, IA-2ic, and insulin were 69.9%, 58.1%, and 45.2%, respectively. The prevalence of IA-2ic autoantibodies in patients with childhood-onset type 1 diabetes (aged
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