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Plasticity of Pax-5(-/-) pre-B I cells
Ludovica Bruno1, Christoph Schaniel, Antonius Rolink
1Basel Institute for Immunology, Basel, Switzerland. lbruno@icr.ac.uk
Cells, Tissues, Organs
|May 22, 2002
Abstract:
In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5(-/-) pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.