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Presenile dementia syndromes: an update on taxonomy and diagnosis
M D Greicius1, M D Geschwind, B L Miller
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Journal of Neurology, Neurosurgery, and Psychiatry
|May 23, 2002
Abstract:
The four major degenerative dementias that often begin in presenescence: are reviewed. These are Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, and Creutzfeldt-Jakob disease. Their epidemiological, genetic, and clinical features are reviewed, and controversies in taxonomy arising from recent discoveries described. Particular attention is given to the pathological role of protein aggregation, which appears to be a factor in each disease.