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Updated: Aug 8, 2026

Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
Short-term regulation of insulin gene transcription
Barbara Leibiger1, T Moede, S Uhles
1The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, Karolinska Institutet, S-17176 Stockholm, Sweden. barbara.leibiger@molmed.ki.se
Abstract:
Short-term regulation of insulin gene transcription is still a matter of debate. However, an increasing body of evidence shows that insulin gene transcription is affected by signals, such as incretins, glucose metabolites, intracellular Ca2+, and by insulin secreted from pancreatic beta-cells, all supporting the concept of an immediate response resulting in insulin gene transcription following food-uptake. The present review aims to summarize the current view on the mechanisms underlying the up-regulation of insulin gene transcription in response to glucose, the major nutrient factor in insulin secretion and biosynthesis.
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