Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rheumatoid synovitis: complement and immune complexes.

P H Schur, M C Britton, A E Franco

    Rheumatology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Novel case of combination antibiotic therapy for treatment of a complicated polymicrobial urinary tract infection with one organism harboring a metallo-β-lactamase (MBL) in a pregnant patient.

    IDCases·2024
    Same author

    Development of SLE among "potential SLE" patients seen in consultation: long-term follow-up.

    International journal of clinical practice·2014
    Same author

    Multipoint targeting of the PI3K/mTOR pathway in mesothelioma.

    British journal of cancer·2014
    Same author

    Clinical manifestations and survival among adults with (SLE) according to age at diagnosis.

    Lupus·2014
    Same author

    AXL regulates mesothelioma proliferation and invasiveness.

    Oncogene·2010
    Same author

    Hemolytic assay of the ninth complement component: elevation and depletion in rheumatic diseases.

    The Journal of experimental medicine·2009
    Same journal

    Blood and tissue distribution of lymphocytes in rheumatoid arthritis.

    Rheumatology·1975
    Same journal

    Enhancement of immunoglobulin and rheumatoid factor synthesis by rheumatoid synovial effusions and synovial membrane culture supernatants.

    Rheumatology·1975
    Same journal

    Screening of cellular immunity in patients with rheumatoid arthritis by phytohaemagglutinin skin test.

    Rheumatology·1975
    Same journal

    Complement activation in seropositive and seronegative rheumatoid arthritis. 125I-C1q binding capacity and complement breakdown products in serum and synovial fluid.

    Rheumatology·1975
    Same journal

    Thermal inactivation and gradient studies of the active agent in rheumatoid arthritis.

    Rheumatology·1975
    Same journal

    Co-cultivation of human cell lines with synovial fluids of patients with rheumatoid arthritis.

    Rheumatology·1975
    See all related articles

    Rheumatoid arthritis joint inflammation involves the complement system, activated by immune complexes. Low complement levels in rheumatoid arthritis patients correlate with severe disease and specific joint damage.

    Area of Science:

    • Immunology
    • Rheumatology
    • Molecular Biology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
    • The role of the complement system in RA pathogenesis is not fully understood.
    • Immune complexes are implicated in the inflammatory processes of RA.

    Purpose of the Study:

    • To investigate the pattern of complement component utilization in the joints of RA patients.
    • To correlate complement levels with clinical and radiological features of RA.
    • To elucidate the role of complement activation in rheumatoid joint inflammation.

    Main Methods:

    • Immunofluorescence studies of synovial fluid (SF) leukocytes.
    • Analysis of immunoglobulin and complement component inclusions within SF cells.

    Related Experiment Videos

  • Assessment of clinical, radiological, and pathological features in RA patients.
  • Evaluation of systemic complement levels.

    • Main Results:

    • Complement utilization in RA joints suggests activation by immune complexes.
    • Intracytoplasmic inclusions of immunoglobulins and complement were found in SF leukocytes.
    • Low SF complement levels were associated with unremitting RA, nodules, gold treatment, and more severe joint damage (radiological and pathological).
    • Systemic hypocomplementemia indicated active RA with severe joint involvement and vasculitis.

    Conclusions:

    • Rheumatoid joint inflammation is mediated by the immunologic activation of the complement system.
    • Complement activation via immune complexes plays a significant role in RA pathogenesis.
    • Complement levels can serve as a marker for disease severity and activity in RA.