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Optimization in development of acetaminophen syrup formulation
Nimit Worakul1, Wibul Wongpoowarak, Prapaporn Boonme
1Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Thailand.
Drug Development and Industrial Pharmacy
|May 25, 2002
Summary
This study optimized acetaminophen syrup formulations using cosolvents to improve solubility and taste while reducing costs. A simulation program determined ideal cosolvent amounts for desirable acetaminophen syrup formulations.
Area of Science:
- Pharmaceutical Sciences
- Computational Chemistry
Background:
- Acetaminophen exhibits low solubility in water, necessitating cosolvents for syrup formulation.
- Optimizing syrup formulations can reduce development time and cost.
Purpose of the Study:
- To develop an optimized acetaminophen syrup formulation using an advanced technique.
- To investigate the impact of various cosolvents on acetaminophen solubility, pH, taste, and cost.
Main Methods:
- Utilized polyethylene glycol 4000, propylene glycol, sorbitol solution, and glycerin as cosolvents.
- Employed simulated annealing and heuristic optimization algorithms for simulation.
- Developed a Visual Basic program within Microsoft Access 97 for automated assessment.
Main Results:
- Identified optimal cosolvent combinations to enhance acetaminophen solubility and desirable formulation characteristics.
- The simulation accurately predicted formulation scores based on cosolvent properties.
- The developed program allows formulators to customize formulations based on specific criteria and cost.
Conclusions:
- An optimization technique effectively developed acetaminophen syrup formulations.
- Cosolvent selection is critical for solubility, pH, taste, and cost-effectiveness.
- The computational approach provides a flexible tool for pharmaceutical formulators.