[Electron microscopic study of the interaction between neoplastic fibroblasts and the substrate in tissue culture]

Electron microscope study of neoplastic L fibroblasts was carried out in 15, 30, 60, and 90 min after their attachment to solid substratum. Comparative analysis of neoplastic and normal fibroblasts at the same stages was carried out. Spreading rate of L fibroblasts proved slower than that of normal fibroblasts. Primary reaction of neoplastic cells was disturbed on the contact with substratum: it was morphologically manifested in changing of structure of the cell lower surface. Bundles of microfilaments were absent from the neoplastic fibroblasts' cytoplasm. The above changes, apparently, may entail the lesser degree of spreading and the weaker attachement of neoplastic fibroblasts to the substratum.