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Recurrent acute epiglottitis in adults: defective antibody response
Rémi Gagnon1, Pierre-Michel Bédard, Louise Côté
1Allergy and Immunology Department, Centre Hospitalier Université Laval, Sainte-Foy, Québec, Canada.
Background:
Recurrent acute epiglottitis is uncommon in adults. In the medical literature, very little is known about the immune status of this population.
Objective:
To evaluate the immune system of a group of four adult patients with recurrent acute epiglottitis, in what represents the largest series ever reported.
Methods:
The clinical course of these episodes was carefully evaluated and a basic immune deficiency work-up was carried out for each patient.
Results:
All four patients displayed clinical and laboratory evidence of impaired humoral immunity. One patient was splenectomized. Another patient had a below normal immunoglobulin G level. At the time of their first evaluation, none of our patients had specific antibodies against Haemophilus influenzae and one had a subnormal Streptococcus pneumoniae immunoglobulin G level for a majority of serotypes. After specific vaccination, two patients had persistent abnormalities in their response to one or more polysaccharides or conjugate-polysaccharide antigens. In the other two, the transient abnormalities were corrected by immunization.
Conclusions:
When recurrent acute epiglottitis occurs in adults, it is important to investigate the immune system because a quantitative or a specific antibody deficiency could be found. It also follows that these patients will be successfully treated either by immunization or antibody replacement.